Projected seeding is based on team ratings from TheRankerPit.com.
A few noteworthy differences with consensus projections from the Bracketology community (found at bracketmatrix.com)
- Duke keeps the overall top seed
- St. Bonaventure and Boise State move up to 10-seeds
- 12-seed Houston replaced SMU as projected American Athletic Conference champion
- 12-seed New Mexico State replaced Grand Canyon as projected Western Athletic Conference champion
| 1 | Duke | 1 | Villanova | |
| 16 | Rider | 16 | Lipscomb | |
| 8 | Wichita St. | 8 | Clemson | |
| 9 | Auburn | 9 | Notre Dame | |
| 5 | Tennessee | 5 | Creighton | |
| 12 | Western Ky. | 12 | Houston | |
| 4 | Oklahoma | 4 | Florida St. | |
| 13 | Murray St. | 13 | Texas-Arlington | |
| 6 | Louisville | 6 | Arizona | |
| 11 | St. Mary’s (CA) | 11 | Oklahoma St. | |
| 3 | Seton Hall | 3 | North Carolina | |
| 14 | East Tenn. St. | 14 | Penn | |
| 7 | Oregon | 7 | Butler | |
| 10 | Michigan | 10 | Penn St. | |
| 2 | West Virginia | 2 | Arizona St. | |
| 15 | Vermont | 15 | Towson | |
| 1 | Purdue | 1 | Michigan St. | |
| 16 | Hampton/Prairie View | 16 | Bucknell/Wagner | |
| 8 | Cincinnati | 8 | St. John’s (NY) | |
| 9 | Maryland | 9 | UNLV | |
| 5 | Texas A&M | 5 | Gonzaga | |
| 12 | New Mexico St. | 12 | South Dakota | |
| 4 | TCU | 4 | Virginia | |
| 13 | Stephen F. Austin | 13 | Portland St. | |
| 6 | Nevada | 6 | Virginia Tech | |
| 11 | UNI/Texas | 11 | Minnesota/Miami (FL) | |
| 3 | Xavier | 3 | Arkansas | |
| 14 | Buffalo | 14 | Northern Ky. | |
| 7 | SMU | 7 | Kentucky | |
| 10 | St. Bonaventure | 10 | Boise St. | |
| 2 | Kansas | 2 | Texas Tech | |
| 15 | Liberty | 15 | UC Santa Barbara |